Zyloric 300 mg

Zyloric (Allopurinol 300 mg) reduces uric acid formation by inhibiting the enzyme xanthine oxidase, thus preventing urate crystal build-up in joints (gout), kidney stones, and during high cell turnover (e.g., chemotherapy) Drugs.com Medicines.org.uk Wikipedia . Usage Initiate at lower doses (100–200 mg/day) and escalate if response is inadequate Moderate cases: 300–600 mg/day; severe: up to 900 mg/day in divided doses if needed Gardenia Pharmacies lynchspharmacy.com Take once daily after meals for tolerance; divided dosing may help if exceeding 300 mg/day Medicines.org.uk lynchspharmacy.com Dose adjustments required in renal or hepatic impairment Medicines.org.uk Gardenia Pharmacies Not recommended for breastfeeding; use cautiously in pregnancy Medicines.org.uk Side Effects & Warnings Watch for serious skin reactions: DRESS, Stevens–Johnson Syndrome, toxic epidermal necrolysis—stop immediately if rash or flu-like symptoms appear Medicines.org.uk patient-info.co.uk Rare effects: agranulocytosis, liver dysfunction, neuropathy, depression,azoemia, and more Medicines.org.uk Wikipedia Risk factors: HLA-B*5801 allele carriers (especially of Asian descent) have heightened hypersensitivity risk Medicines.org.uk Wikipedia May trigger an initial gout flare—often co-prescribed with colchicine during initiation YouTube Reddit Numerous drug interactions: azathioprine, amoxicillin, warfarin, diuretics, ACE inhibitors, etc.—inform your provider of all medications patient-info.co.uk lynchspharmacy.com Treatment Duration Often lifelong for chronic hyperuricemia; abrupt cessation may trigger severe flares Reddit +1 Reddit +1 User Insights (Reddit Highlights) “Taking allopurinol for the first time may cause a flare up if not combined with something like colchicine. … Allopurinol is a lifer drug.” Reddit “…once started it must be taken life long… Do not stop taking them without talking to your rheumatologist.