Zyloric 150 mg (Allopurinol)

Zyloric (Allopurinol) works by inhibiting the enzyme xanthine oxidase, which reduces uric acid production, thereby preventing crystallization and accumulation in joints and renal tissues. It’s indicated for: Gouty arthritis, skin tophi, uric acid nephrolithiasis Hyperuricemia during malignancy or high cell turnover states Specific metabolic enzyme disorders like Lesch–Nyhan syndrome Management of renal 2,8-DHA stones or recurrent calcium oxalate stones associated with hyperuricosuria RxReasoner MedicineP Dosage Guidelines (Adults): Start at 100 mg daily after a meal to minimize GI upset Mild cases: 100–200 mg/day Moderate: 300–600 mg/day (often in divided doses) Severe: up to 700–900 mg/day as clinically required Always adjust based on serum urate levels and renal/hepatic function RxReasoner Medicines.org.uk MIMS Special Populations & Precautions: Renal impairment: lower doses or extended dosing intervals are required; dialysis patients may need post-dialysis dosing (300–400 mg) Hepatic dysfunction: dose reduction and periodic liver function monitoring recommended Elderly: use the lowest effective dose anagen.net RxReasoner Key Risks & Side Effects: Common: rash, nausea, drowsiness, elevated liver enzymes Rare but serious: Stevens–Johnson syndrome, toxic epidermal necrolysis—especially among certain ethnic groups or those with renal impairment—requires immediate discontinuation Medicines.org.uk patient-info.co.uk lynchspharmacy.com Drug Interactions: Increases effects or toxicity of azathioprine, 6-mercaptopurine Interaction with ACE inhibitors, diuretics, warfarin, theophylline May exacerbate reactions if taken with ampicillin/amoxicillin