Colchicine 1 mg

Mechanism of Action Colchicine reduces inflammation by inhibiting neutrophil activity—specifically chemotaxis, inflammasome action, and microtubule polymerization—thereby alleviating acute gout symptoms and preventing recurrent attacks. Wikipedia +1 Wikipedia +1 Dosage Guidelines Acute gout flare: Initial dose often 1–2 mg, followed by 0.5–1 mg 1 hour later—capped at 1.8 mg within an hour, or 6 mg within 24 hours depending on the formulation. Wikipedia Amkamed Pharmaceuticals Prophylaxis (prevention): Typically 0.6 mg once or twice daily, not exceeding 1.2 mg/day. Mayo Clinic Wikipedia Key Precautions & Interactions Kidney or liver impairment: Dose adjustments are required in such patients. Practo Wikipedia Interactions: Avoid concurrent use with strong CYP3A4 or P-gp inhibitors (e.g., clarithromycin, erythromycin) due to increased toxicity risk. Wikipedia BAD Patient Hub Grapefruit: Should be avoided as it increases colchicine blood levels. Healthline BAD Patient Hub Common Side Effects Mild: Diarrhea, nausea, abdominal pain. WebMD Healthline Severe (rare): Muscle toxicity/rhabdomyolysis, blood dyscrasias (e.g. leukopenia), and neuropathies. Drugs.com Wikipedia Use in Special Conditions Also used therapeutically in Familial Mediterranean Fever and pericarditis, often requiring extended treatment durations.¶ Wikipedia Reddit Patient and Peer Insights Many users note strong gastrointestinal distress—“It gives me a runny stomach almost every time” Reddit . Some report neurological side effects (e.g., tingling or tremors), which typically improve on discontinuation. Reddit Others use low-dose colchicine long-term (e.g., 0.5 mg daily) for heart health or chronic inflammatory conditions, noting potential cardiovascular benefits.