Allopurinol 300 mg

Mechanism & Uses Allopurinol works by blocking the enzyme xanthine oxidase, lowering uric acid synthesis to prevent gout, kidney stones, tumor lysis syndrome, and conditions like Lesch-Nyhan syndrome. Medicines.org.uk Drugs.com Wikipedia Dosage Typical adult dosage ranges from 100–900 mg daily, starting at 100–300 mg and increasing as needed. patient-info.co.uk Mayo Clinic In kidney impairment, dose adjustments and close monitoring are required. Medicines.org.uk patient-info.co.uk Takes weeks to months for full therapeutic effect. Medicover Hospitals Drugs.com Side Effects & Precautions Common: rash, nausea, diarrhea, drowsiness. Apollo Hospitals Drugs.com Wikipedia Severe risks include hypersensitivity syndrome (DRESS), Stevens–Johnson Syndrome, TEN—mortality rates 20–25%, especially in renal-compromised or HLA-B*5801 allele carriers. Wikipedia +2 Wikipedia +2 Wikipedia +2 Regular blood, liver, and kidney monitoring recommended; discontinue at first sign of rash or flu-like symptoms. Drugs.com MedBroadcast Wikipedia Patient Perspective (Reddit Insights) “Starting with 100 mg and titrating up helps minimize flares.” — supports the “low-and-slow” start approach Reddit “First few weeks can feel like pins and needles, then relief follows.” — acknowledges transient discomfort early in therapy